In this movie, we can observe macrophages and T-cells interacting. Naive T-cells are being presented with antigens by the macrophages which “instruct” T-cells on what type of cells to target (such as cancer cells) and kill. During this interaction, T-cells can play a role in immune system homeostasis (Andersen, 2018) by killing the macrophage presenting the antigen. . It was documented that the event is triggered by the presence of specific markers on the macrophage surface (called TRAIL and TWEAK (Kaplan et al., 2018)) telling T-cells to induce apoptosis of their fellow macrophage. The dead macrophage is then seen to be recycled by other macrophages, making space for new macrophages to be produced while keeping the same overall macrophage population.
More Amazing macrophage movies at https://nanolive.ch/macrophages/